Honey has been used for wound care since ancient Egyptian times. At that time, they used honey to keep away evil spirits, something that now have been found to be microorganisms. Nowadays, it is widely recognized that medical grade honey enhances wound healing and exerts antimicrobial activities. Many different honey-based wound care products exist. Two products that are frequently used for wound care are medical grade honey-based L-Mesitran Soft and manuka honey-based Medihoney. The antimicrobial activity of these two commercially available medical grade honey products against Staphylococcus and Pseudomonas bacteria was investigated.
L-Mesitran contains 40% medical grade honey and is supplemented with vitamins C and E and carriers to make it easy to apply as a cream. Medihoney contains 80% manuka-honey. In this study, the concentrations of both products at which they are effective to stop the growth and to kill Staphylococcus (including MRSA) and Pseudomonas bacteria were evaluated. To get a reliable result, tests were done on 11 bacterial isolates of both species against two different bacterial concentrations.
L-Mesitran showed more consistent and significantly stronger killing activity than Medihoney, despite containing half the amount of honey in its formulation. Likely, the supplements in L-Mesitran have enhanced its activity.